GC/MS
Gas Chromatography Mass Spectrometry (GC/MS) is a technique for the separation, detection, and identification of volatile and semi-volatile organic compounds. As the name implies, it is actually two techniques that are combined to form a single method of analyzing mixtures of chemicals. Gas chromatography separates the components of a mixture and mass spectroscopy characterizes each of the components individually. By combining the two techniques, an analytical chemist can both qualitatively and quantitatively evaluate a solution containing a number of chemicals. A sample is introduced into a thin capillary column through which a carrier gas (Helium) is flowing. The carrier gas carries the sample mixture through what is referred to as a stationary phase. The stationary phase is a usually chemical that can selectively attract components in a sample mixture. The mixture of compounds in the carrier gas interacts with the stationary phase. Each compound in the mixture interacts at a different rate. Compounds emerge from the column into the mass spectrometer (MS) as separate molecular bands. There, they are bombarded with a stream of electrons causing them to break apart into fragments. These fragments can be large or small pieces of the original molecules. The result is a quantitative analysis and mass spectrum for each component.
Instrument Capabilities
- GC-MS system HP 5890 with 5972 MS detector featuring:
- Molecular ions up to m/z 1000
- Direct Liquid Injection
- Heated Headspace
Applications
- Process impurity identifications
- Development of a tailored study design for extractables and leachables
- Extractables profiling (both organic and inorganic)
- Degradation product identification
- Deformulation of products
- Identification of unknown impurities
- Identification and characterization of reaction by-products
- Raw Materials Lot-Lot and Vendor-Vendor Active Ingredient (API) and impurity comparisons.
- Structural hit list screening for potent impurities (i.e. melamine, alkylating agents).
- Polymeric material characterization
- Patent litigation support
Gas Chromatography Mass Spectrometry (GC/MS) is a powerful technique used to separate, detect, and identify volatile and semi-volatile organic compounds. By combining gas chromatography and mass spectrometry, GC/MS allows for qualitative and quantitative analysis of chemical mixtures. Alera Labs utilizes a high-performance GC/MS system with advanced capabilities for accurate and reliable results. Our instrument features a 5972 MS detector, enabling the detection of molecular ions up to m/z 1000. With direct liquid injection and heated headspace capabilities, we ensure efficient and precise sample analysis.
Trust Alera Labs for comprehensive GC/MS services, providing quantitative analysis and detailed mass spectra for each component in your sample.
Pharmaceutical Industry:
Identification and quantification of volatile and semi-volatile organic compounds
Agbio Industry:
Identification and quantification of volatile and semi-volatile organic compounds
Biotechnology:
Identification and quantification of volatile and semi-volatile organic compounds
Medical Devices Industry:
Identification and quantification of volatile and semi-volatile organic compounds
Chemical Industry:
Identification and quantification of volatile and semi-volatile organic compounds